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Clinical Guide · Substance Use

Alcohol Use Disorder: Understanding It and Getting Evidence-Based Treatment

Medically reviewed byDr. Sarah Chen, Psy.D· May 2026

Alcohol use disorder (AUD) is a chronic brain condition affecting approximately 28 million Americans. Despite being among the most prevalent and costly conditions in the United States, only about 7% of people with AUD receive any treatment. Effective, evidence-based treatments exist — including medications most people don't know about.

Understanding alcohol use disorder

AUD is diagnosed on a spectrum from mild to severe based on the number of diagnostic criteria met. These include: drinking more or longer than intended; persistent desire or failed attempts to cut down; spending significant time obtaining, using, or recovering from alcohol; giving up important activities due to drinking; continued use despite physical or psychological harm; tolerance (needing more for the same effect); and withdrawal symptoms when stopping.

Medications for alcohol use disorder

Three FDA-approved medications treat AUD — yet most people receiving treatment never receive medication. Naltrexone (oral daily or Vivitrol monthly injection) reduces cravings and the rewarding effects of alcohol — response rates of 50-60%. Acamprosate (Campral) reduces withdrawal-related distress and anxiety. Disulfiram (Antabuse) causes aversive reaction to alcohol, useful when supervised. Any primary care physician or psychiatrist can prescribe these; a specialist is not required.

Behavioral treatments

Cognitive Behavioral Therapy, Motivational Enhancement Therapy, 12-step facilitation, and SMART Recovery are all evidence-based behavioral approaches. The COMBINE trial found that medication plus behavioral intervention produces the best outcomes. Mutual help groups (AA, SMART Recovery) provide ongoing peer support that improves long-term outcomes.

Sources & further reading
Content is based on peer-reviewed research and clinical guidelines from NIMH, APA, SAMHSA, and specialty professional organizations. Editorial standards →
Frequently asked questions
No — treatment goals should be individualized. While abstinence produces the best outcomes for severe AUD, significant harm reduction through moderated drinking is a legitimate goal, particularly for mild-moderate AUD. Naltrexone can be effective with a harm reduction approach (the Sinclair Method). Discuss your goals honestly with your treatment provider.
Alcohol withdrawal can be medically serious and potentially fatal — unlike most other substances. Seizures and delirium tremens (DTs) can occur, particularly in heavy drinkers with long drinking histories. Anyone with significant physical dependence should detox under medical supervision. Consult a physician before stopping heavy, daily drinking.
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