Mental Health Blog · May 2026

Ketamine Therapy for Treatment-Resistant Depression: What to Know

Rapid antidepressant effects, who's a candidate, how to find a legitimate ketamine provider — a research-based overview of ketamine for depression.

Note: This article provides educational information only. It is not a substitute for professional mental health advice, diagnosis, or treatment. If you are experiencing a mental health crisis, please call or text 988.

Overview

Ketamine infusion therapy and intranasal esketamine (Spravato) are FDA-approved for treatment-resistant depression. Here's what the evidence shows and what treatment involves. This guide covers what the current evidence shows, what to look for in providers, and how to take practical next steps.

What you need to know

Understanding the landscape of ketamine therapy for treatment-resistant depression helps you make better decisions about your care. The most important factors are the quality and training of your provider, whether the approach matches your specific needs, and your own active engagement in the process.

Finding the right provider

Use BehavioralHealthGuide.org to search for providers with specific experience in this area. Filter by insurance, location, and whether they offer telehealth. An initial phone consultation before your first appointment is always worthwhile — ask directly about their experience and approach.

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